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- Leptin.
- Leptin (from the Greek leptos, meaning “thin”) is a protein hormone with important roles in regulating body weight, metabolism, and reproductive function. It is the product of the LEP gene, the human analogue of the ob (short for "obese") gene in mice, located at 7q32.1 on the human chromosome. Leptin is produced primarily by white adipocytes (fat cells). It is also produced by brown adipocytes, bone marrow, and epithelial cells of the stomach and the placenta, among other organs. As adipocytes increase in size because of accumulation of triglycerides (fat molecules), they synthesize more and more leptin. The mechanism by which leptin production is controlled is not fully understood, but a number of hormones are known to modulate leptin output, including insulin and melatonin....
- Salem Press Encyclopedia of Science, 2023. 2p.
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