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Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis.

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issue: Nature medicine [Nat Med] 2024 May 09. Date of Electronic Publication: 2024 May 09.
Author: Thomas MF; Department of Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA. thomamol@ohsu.edu.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. thomamol@ohsu.edu.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. thomamol@ohsu.edu.; Harvard Medical School, Boston, MA, USA. thomamol@ohsu.edu.; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. thomamol@ohsu.edu.; Division of Gastroenterology, Department of Medicine, Oregon Health and Sciences University, Portland, OR, USA. thomamol@ohsu.edu.; Department of Cell, Developmental, and Cancer Biology, Oregon Health and Sciences University, Portland, OR, USA. thomamol@ohsu.edu.
Slowikowski K; Department of Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA. kslowikowski@mgh.harvard.edu.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. kslowikowski@mgh.harvard.edu.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. kslowikowski@mgh.harvard.edu.; Harvard Medical School, Boston, MA, USA. kslowikowski@mgh.harvard.edu.
Manakongtreecheep K; Department of Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Sen P; Department of Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Transplant, Oncology, and Immunocompromised Host Group, Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, MA, USA.
Samanta N; Department of Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Tantivit J; Department of Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Nasrallah M; Department of Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Rheumatology, Department of Medicine, North Shore Physicians Group, Mass General Brigham Healthcare Center, Lynn, MA, USA.
Zubiri L; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Smith NP; Department of Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Tirard A; Department of Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Ramesh S; Department of Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Arnold BY; Department of Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Nieman LT; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Chen JH; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Eisenhaure T; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Pelka K; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Song Y; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Xu KH; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Jorgji V; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Pinto CJ; Clinical Research Center, Massachusetts General Hospital, Boston, MA, USA.
Sharova T; Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Glasser R; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Chan P; Harvard Medical School, Boston, MA, USA.; Clinical Research Center, Massachusetts General Hospital, Boston, MA, USA.
Sullivan RJ; Harvard Medical School, Boston, MA, USA.; Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Khalili H; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Juric D; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Boland GM; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Dougan M; Harvard Medical School, Boston, MA, USA.; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Hacohen N; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.
Li B; Department of Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Genentech, South San Francisco, CA, USA.
Reynolds KL; Harvard Medical School, Boston, MA, USA.; Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Villani AC; Department of Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, USA. avillani@mgh.harvard.edu.; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. avillani@mgh.harvard.edu.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. avillani@mgh.harvard.edu.; Harvard Medical School, Boston, MA, USA. avillani@mgh.harvard.edu.
DB Label: Database : MEDLINE

원문보기: Full Text (Nature) 조회 - Impact Factor (JCR)

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