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1
Novel multisubstrate inhibitors of mammalian purine nucleoside phosphorylase 미리보기

학술저널

issue
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY; NOV 2005, 61 p1449-p1458, 10p.
Author
Toms, AV
Wang, WR
Li, YB
Ganem, B
Ealick, SE
DB Label
Database : Science Citation Index Expanded
원문보기
Full Text Full Text (원문보기) Full Text (Wiley-DB)  등재 - Web of Science  등재 - SCOPUS 
4
Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279. 미리보기

학술저널

issue
Journal of medicinal chemistry [J Med Chem] 2023 Aug 10; Vol. 66 (15), pp. 10473-10496. Date of Electronic Publication: 2023 Jul 10.
Author
Leit S; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Greenwood J; Schrödinger, Inc., 1540 Broadway, New York, New York 10036, United States.
Carriero S; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Mondal S; Schrödinger, Inc., 1540 Broadway, New York, New York 10036, United States.
Abel R; Schrödinger, Inc., 1540 Broadway, New York, New York 10036, United States.
Ashwell M; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Blanchette H; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Boyles NA; Schrödinger, Inc., 1540 Broadway, New York, New York 10036, United States.
Cartwright M; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Collis A; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Feng S; Schrödinger, Inc., 1540 Broadway, New York, New York 10036, United States.
Ghanakota P; Schrödinger, Inc., 1540 Broadway, New York, New York 10036, United States.
Harriman GC; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Hosagrahara V; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Kaila N; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Kapeller R; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Rafi SB; Schrödinger, Inc., 1540 Broadway, New York, New York 10036, United States.
Romero DL; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Tarantino PM; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Timaniya J; Piramal Pharma Solutions, Plot No. 18, Pharmez, Ahmedabad 382215, Gujarat, India.
Toms AV; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Wester RT; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Westlin W; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Srivastava B; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Miao W; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Tummino P; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
McElwee JJ; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Edmondson SD; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
Masse CE; Nimbus Therapeutics, 22 Boston Wharf Road, Floor 9, Boston, Massachusetts 02210, United States.
DB Label
Database : MEDLINE
원문보기
Full Text (ACS)  등재 - Web of Science (SCIE)  등재 - SCOPUS  조회 - Impact Factor (JCR) 
5
Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis. 미리보기

학술저널

issue
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Oct 01; Vol. 73, pp. 128891. Date of Electronic Publication: 2022 Jul 13.
Author
Leit S; Nimbus Therapeutics, 130 Prospect St., Cambridge, MA 02139, United States. Electronic address: silvana.leit@nimbustx.com.
Greenwood JR; Schrodinger, Inc., 1540 Broadway, New York, NY 10036, United States.
Mondal S; Schrodinger, Inc., 1540 Broadway, New York, NY 10036, United States.
Carriero S; Nimbus Therapeutics, 130 Prospect St., Cambridge, MA 02139, United States.
Dahlgren M; Schrodinger, Inc., 1540 Broadway, New York, NY 10036, United States.
Harriman GC; Nimbus Therapeutics, 130 Prospect St., Cambridge, MA 02139, United States.
Kennedy-Smith JJ; Schrodinger, Inc., 1540 Broadway, New York, NY 10036, United States.
Kapeller R; Schrodinger, Inc., 1540 Broadway, New York, NY 10036, United States.
Lawson JP; Nimbus Therapeutics, 130 Prospect St., Cambridge, MA 02139, United States.
Romero DL; Nimbus Therapeutics, 130 Prospect St., Cambridge, MA 02139, United States.
Toms AV; Nimbus Therapeutics, 130 Prospect St., Cambridge, MA 02139, United States.
Shelley M; Schrodinger, Inc., 1540 Broadway, New York, NY 10036, United States.
Wester RT; Nimbus Therapeutics, 130 Prospect St., Cambridge, MA 02139, United States.
Westlin W; Nimbus Therapeutics, 130 Prospect St., Cambridge, MA 02139, United States.
McElwee JJ; Nimbus Therapeutics, 130 Prospect St., Cambridge, MA 02139, United States.
Miao W; Nimbus Therapeutics, 130 Prospect St., Cambridge, MA 02139, United States.
Edmondson SD; Nimbus Therapeutics, 130 Prospect St., Cambridge, MA 02139, United States.
Masse CE; Nimbus Therapeutics, 130 Prospect St., Cambridge, MA 02139, United States.
DB Label
Database : MEDLINE
원문보기
Full Text (ScienceDirect)  등재 - Web of Science (SCIE)  등재 - SCOPUS  조회 - Impact Factor (JCR) 
7
Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor. 미리보기

학술저널

issue
Journal of medicinal chemistry [J Med Chem] 2020 Feb 27; Vol. 63 (4), pp. 1612-1623. Date of Electronic Publication: 2020 Feb 12.
Author
Caravella JA; FORMA Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Lin J; FORMA Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Diebold RB; FORMA Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Campbell AM; FORMA Therapeutics, Inc. , Branford , Connecticut 06405 , United States.
Ericsson A; FORMA Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Gustafson G; FORMA Therapeutics, Inc. , Branford , Connecticut 06405 , United States.
Wang Z; FORMA Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Castro J; FORMA Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Clarke A; FORMA Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Gotur D; FORMA Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Josephine HR; FORMA Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Katz M; FORMA Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Kershaw M; FORMA Therapeutics, Inc. , Branford , Connecticut 06405 , United States.
Yao L; FORMA Therapeutics, Inc. , Branford , Connecticut 06405 , United States.
Toms AV; FORMA Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Barr KJ; FORMA Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Dinsmore CJ; FORMA Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Walker D; FORMA Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Ashwell S; FORMA Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Lu W; FORMA Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
DB Label
Database : MEDLINE
원문보기
Full Text (ACS)  등재 - Web of Science (SCIE)  등재 - SCOPUS  조회 - Impact Factor (JCR) 
8
Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors. 미리보기

학술저널

issue
Journal of medicinal chemistry [J Med Chem] 2019 Jul 25; Vol. 62 (14), pp. 6575-6596. Date of Electronic Publication: 2019 Jul 08.
Author
Lin J; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Lu W; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Caravella JA; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Campbell AM; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Diebold RB; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Ericsson A; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Fritzen E; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Gustafson GR; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Lancia DR Jr; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Shelekhin T; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Wang Z; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Castro J; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Clarke A; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Gotur D; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Josephine HR; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Katz M; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Diep H; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Kershaw M; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Yao L; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Kauffman G; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Hubbs SE; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Luke GP; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Toms AV; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Wang L; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Bair KW; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Barr KJ; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Dinsmore C; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Walker D; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
Ashwell S; Forma Therapeutics, Inc. , 500 Arsenal Street, Suite 100 , Watertown , Massachusetts 02472 , United States.
DB Label
Database : MEDLINE
원문보기
Full Text (ACS)  등재 - Web of Science (SCIE)  등재 - SCOPUS  조회 - Impact Factor (JCR) 
10
Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN). 미리보기

학술저널

issue
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Apr 15; Vol. 29 (8), pp. 1001-1006. Date of Electronic Publication: 2019 Feb 11.
Author
Martin MW; FORMA Therapeutics, 500 Arsenal Street, Suite 100, Watertown, MA 02472, USA. Electronic address: mmartin@formatherapeutics.com.
Lancia DR Jr; FORMA Therapeutics, 500 Arsenal Street, Suite 100, Watertown, MA 02472, USA.
Li H; FORMA Therapeutics, 35 Northeast Industrial Road, Branford, CT 06405, USA.
Schiller SER; FORMA Therapeutics, 500 Arsenal Street, Suite 100, Watertown, MA 02472, USA.
Toms AV; FORMA Therapeutics, 500 Arsenal Street, Suite 100, Watertown, MA 02472, USA.
Wang Z; FORMA Therapeutics, 500 Arsenal Street, Suite 100, Watertown, MA 02472, USA.
Bair KW; FORMA Therapeutics, 500 Arsenal Street, Suite 100, Watertown, MA 02472, USA.
Castro J; FORMA Therapeutics, 500 Arsenal Street, Suite 100, Watertown, MA 02472, USA.
Fessler S; FORMA Therapeutics, 500 Arsenal Street, Suite 100, Watertown, MA 02472, USA.
Gotur D; FORMA Therapeutics, 500 Arsenal Street, Suite 100, Watertown, MA 02472, USA.
Hubbs SE; FORMA Therapeutics, 35 Northeast Industrial Road, Branford, CT 06405, USA.
Kauffman GS; FORMA Therapeutics, 35 Northeast Industrial Road, Branford, CT 06405, USA.
Kershaw M; FORMA Therapeutics, 35 Northeast Industrial Road, Branford, CT 06405, USA.
Luke GP; FORMA Therapeutics, 35 Northeast Industrial Road, Branford, CT 06405, USA.
McKinnon C; FORMA Therapeutics, 500 Arsenal Street, Suite 100, Watertown, MA 02472, USA.
Yao L; FORMA Therapeutics, 35 Northeast Industrial Road, Branford, CT 06405, USA.
Lu W; FORMA Therapeutics, 500 Arsenal Street, Suite 100, Watertown, MA 02472, USA.
Millan DS; FORMA Therapeutics, 500 Arsenal Street, Suite 100, Watertown, MA 02472, USA.
DB Label
Database : MEDLINE
원문보기
Full Text (ScienceDirect)  등재 - Web of Science (SCIE)  등재 - SCOPUS  조회 - Impact Factor (JCR) 
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