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Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial

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issue: In The Lancet 2-8 December 2023 402(10417):2077-2090
Author: Abbasciano, Isabella
Abrantes, Catarina
Accarino, Simone
Adler, Sharon
Adoberg, Annika
Afsari, Rouzbeh
Ahmad, Syeda
Ahmed, Jafar
Ahn, Wooin
Ajayi, Bamidele
Aksamit, Dariusz
Al Chalabi, Saif
Alamartine, Eric
Alchi, Bassam
Ali, Mohammad
Aliotta, Roberta
Almaani, Salem
Almeida, Catarina
Almeida, Edgar
Alvarez, Francisco de la Prada
Alves, Patricia
Annese, Francesca
Appel, Gerald
Arduan, Alberto Ortiz
Arena, Maria
Arevalo, Marta Calvo
Arfaania, Dariush
Arias, Carlos
Aristoy, Emma Calatayud
Asakiene, Egle
Ashley, Sarah
Assefi, Ali
Atenza, Alba
Auerbach, Asta
Augustyniak-Bartosik, Hanna
Avella, Monroy
Ayling-Smith, Jonathan
Ayoub, Isabelle
Ayvazyan, Christine
Baccaro, Rocco
Bailey, Asha
Baker, Bruce
Balamuthusamy, Saravanan
Ballarin, Jose
Barata, Rui
Barbic, Jerko
Barisic, Dunja
Barratt, Jonathan
Barreto, Jose Carlos de Jesus
Barrios, Clara
Belingheri, Mirco
Benesova, Anna
Bernabeu, Ana Avila
Bernhardt, Wanja
Bhadra, Shamik
Biancone, Luigi
Blanchard, Anne
Boaglio, Elena
Bolignano, Davide
Bomback, Andrew
Bonilla, Gustavo Andres Useche
Bordoli, Monica
Bose, Bhadran
Boudville, Neil
Brandon, Donald
Brown, Karen
Broyet, Christian
Bucknall, Thomas
Buffet, Alexandre
Bumblyte', Inga Arune
Burdese, Manuel
Burgos, Natalia Allende
Burguet, Laure
Burtey, Stephane
Busch, Martin
Cakiroglu, Figen
Campbell, Victoria
Canetta, Pietro
Capaccio, Flavia
Carbonell, Juan
Cardoso, Filipa
Carro, Clara Garcia
Carroll, Robert
Carron, Pierre-Louis
Carullo, Nazareno
Cassia, Matthias
Caster, Dawn
Castillo, Belen Vizcaino
Catucci, Davide
Cavalli, Andrea
Chae, Dong-Wan
Chakera, Aron
Chan, Doris
Chan, Gary Chi Wang
Chan, Anthony Ting Pong
Chan, Lai Wan
Chang, Jae Hyun
Chang, Ming-Shan
Chapman, Fiona
Charytan, Chaim
Chaudhry, Asghar
Cheetham, Melissa
Chen, Cheng-Hsu
Chen, Hsin-Yu
Chen, Chien-Liang
Chen, Hung-Yuan
Chen, Hung-Chun
Chenine, Leila
Cheung, Siu Fai
Cheung, Chee Kay
Chiche-Jourde, Noemie
Chiu, Hsien-Fu
Chiu, Yen-Ling
Chiu, Yi-Wen
Chiu, Ian
Choi, Hoon Young
Chou, Kang-Ju
Chowdhury, Paramit
Chowdhury, Pradip
Chrysochou, Constantina
Chukwu, Chukwuma
Chun, Ka Yeong
Chung, Wookyung
Cieniawski, Dominik
Claisse, Guillaume
Clayton, Philip
Cleary, Catalina Martín
Clement, Nisha
Coates, Toby
Cogno, Chiara
Colla, Loredana
Collins, Michael
Colucci, Marco
Combe, Christian
Comi, Nicolino
Comunale, Roderick
Contreras, Gabriel
Cooper, Bruce
Coppock, Gaia
Costa, Ana Cortesão
Costanzi, Stefano
Cozzolino, Mario
Crail, Susan
Cunha, Liliana
Curry, Elizabeth
Dai, Tiane
Daina, Erica
Daneshvari, Sam
Dasgupta, Indranil
DaSilva, Louise
Davidson, Robert
De Bhailis, Aine Maire
de Précigout, Valérie
Decupere, Marc
Delmas, Yahsou
Deodato, Francesca
Dhaun, Neeraj
Dhaygude, Ajay
Dhelaria, Ranjit
Di Maio, Federica
Diezhandino, Maria Angeles Goicoechea
Dika, Zivka
Dinic, Miriana
Dittmer, Ian
Dobre, Mirela
Doctor, Gabriel
Donati, Gabriele
Doubel, Peter
Douthit, Nicole
Draganova, Diliana
Drexler, Yelena
Drinkovic, Martin
Drinovska, Klara
Dudreuilh, Caroline
Dumond, Clement
Durlen, Ivan
Dussol, Bertrand
Encarnacion, Montserrat Diaz
Endre, Zoltan
Enrique, Jorge
Eqbal, Yusuf
Erlich, Jonathan
Esposito, Vittoria
Esposito, Ciro
Fakih, Faisal
Fang, Hua-Chang
Farinha, Ana
Fearday, Aaron
Felgueiras, Joana de Sousa Soares
Felicjanczuk, Elzbieta
Fernandes, João Carlos
Fernandes, Sara
Fernandes, Adriana
Fernandez, Jose Luño
Fernandez, Victor
Fernando, Mangalee
Figueiredo, Ana Carolina
Firre, Eric
Floege, Jürgen
Flossmann, Oliver
Floyd, Lauren
Fonseca, Nuno
Fonseca, Jose Nuno de Almeida Agapito
Foote, Celine
Forbes, Suzanne
Forcen, Angel
Fornoni, Alessia
Fouassier, David
Fraser, Ian
Fung, Ka Shun Samuel
Furlano, Monica
Furtado, Teresa
Gadh, Rajdeep
Gaisset, Roxane
Gallagher, Martin
Gameiro, Joana
Gangadharan, Muralikrishna
Garcia, Fabiola Alonso
Garcia, Olga Gracia
Garg, Gunjan
Garrouste, Cyril
Gautam, Archana
Geara, Abdallah
Geddes, Colin
Gellineo, Lana
Germain, Michael
Gesualdo, Loreto
Ghalli, Farid
Giaroni, Francesco
Giles, Harold
Gillies, Alastair
Gimeno, Ana Vilar
Girardet, Annette
Glaze, Jeffrey
Goh, Tze
Gois, Mario
Goldsmith, Christopher
Goma, Elena
Gomes, Ana Marta
Goncalves, Luis Pedro Falcao
Goncalves, Sara
Gontarek-Kacprzak, Julita
Gonzalez, Carlos
Gopu, Arun
Gowda, Nayan
Gray, Nicholas
Greco, Barbara
Green, Heather
Greze, Clarisse
Griffin, Sian
Guldris, Secundino Cigarran
Guzman, Ursula Verdalles
Ha, Jeffrey Tsun Kit
Hall, Amanda
Hamilton, Patrick
Han, Seung Hyeok
Haws, Robert
Hayat, Ashik
Heath, Lauren
Heinrichs, Sven
Henderson, Andrew
Henderson, Amy
Hendren, Elizabeth
Heng, Anne-Elisabeth
Heres, Salia Virxinia Pol
Herfurth, Johann Konstantin
Herrero, Evangelina Merida
Ho, Tzung-Yo
Hogan, Jonathan
Hohenstein, Bernd
Hollett, Peter
Horvatic, Ivica
Hsu, Bang-Gee
Hsu, Chia-Tien
Hsu, Chih-Yang
Hsu, Shih-Ping
Huang, Chien-Wei
Hudson, Amy
Hung, Chi-Chih
Hwang, Shang-Jyh
Hwang, Daw-Yang
Hyun, Young Youl
Ilmoja, Madis
Irish, Georgina
Jacob, Radu
Jahan, Sadia
Jain, Arunima
Jamar, Sofie
Jander, Anna
Jang, Hye Ryoun
Janko, Catherine
Jardine, Meg
Jaskowski, Piotr
Jeantet, Guillaume
Jelakovic, Bojan
Jeon, Junseok
Jeong, Jong Cheol
Jesudason, Shilpanjali
Jittirat, Arksarapuk
Jo, Sang-Kyung
Jones, Rachel
Joo, Narae
Jorge, Sofia
Julian, Bruce
Jung, JiYong
Jyothinagaram, Praveena
Kadakia, Jigar
Kamal, Fahameedah
Kanigicherla, Durga
Karanovic, Sandra
Karras, Alexandre
Kasimatis, Theodoros
Kassem, Mohamad
Kattamanchi, Siddhartha
Keller, Christopher
Kentric, Dubravka Trajbar
Kettner, Christiane
Khalil, Kassem
Kim, Dana
Kim, Se Joong
Kim, Yeong Hoon
Kim, Yunmi
Kim, Hyung Wook
Kim, Sunggyun
Kim, Jwa-Kyung
Kim, Aejin
Kim, Myung-Gyu
Kimber, Cassandra
Klamm, Kathryn
Koch, Annegret
Koester, Eric
Kolvald, Kulli
Kon, Sui
Kooienga, Laura Ann
Kotwal, Sradha
Krajewska, Magdalena
Kratka, Karolina
Krishnan, Anoushka
Krishnasamy, Rathika
Krueger, Thilo
Kruljac, Ivan
Kulka, Simone
Kunzendorf, Ulrich
Kuo, Mei-Chuan
Kuo, Hung-Tien
Kuo, Sheng
Kwan, Lorraine Pui Yuen
Kwella, Norbert
Kwella, Bogna
Kyaw, Kay
Labat, Aurore
Lafayette, Richard
Lagatta, Mark
Lam, Chi Kwan Darwin
Lambie, Mark
Lanaret, Camille
Latif, Farah
Laute, Margo
Law, Wai Ping
Lawman, Sarah
Lazo, Mercedes Salgueira
Lee, Hajeong
Lee, Moon Hyoung
Lee, Kyu-Beck
Lee, Hyung-seok
Lee, JungEun
Lee, Hyun Hee
Lee, Po-Tsang
Leis, Liisi
Lemahieu, Wim
Leung, Janson
Li, Yan
Lie, Davina Ngoi Wah
Lifland, Howard
Lilienthal, Kadri
Lim, Wai
Limardo, Monica
Livrozet, Marine
Longhi, Selena
Lopes, Daniela
Lopes, Jose Antonio
Lorde, Nathan
Luxton, Grant
Ma, Mingyao
Madhrira, Machaiah
Madonia, Phillip
Maes, Bart
Mahadevan, Kumaradevan
Mahdi, Amar
Mahdi, Eamon
Maillard, Nicolas
Maixnerova, Dita
Majstorovic Barac, Karolina
Malecki, Robert
Malfait, Thomas
Malvica, Silvia
Mandayam, Sreedhar
Manley, Paul
Mansfield, Nick
Marcantoni, Carmelita
Mariat, Christophe
Marin, Tamara Malek
Marin, Lida Maria Rodas
Mark, Patrick
Marques, Joana
Martinez, Eduardo Gutierrez
Martinez, Stacy
Masset, Catherine
Masson, Ingrid
Mather, Amanda
Maung Myint, Thida Maung
Mayet, Valentin
McCafferty, Kieran
McCarthy, Ellen
McDonald, Stephen
McGreal, Kerri
McMahon, Kellyn
McNally, Andrew
McQuarrie, Emily
Medina, Allyson
Meeus, Gert
Mehta, Kshama
Mendoza, Elder
Menezes, Maria
Meng, Jerry
Messa, Piergiorgio
Messias, Ana
Miarka, Przemyslaw
Miglinas, Marius
Mikacic, Ivana
Mikhail, Ashraf
Milicevic, Martina
Minasian, Raffi
Moeller, Marcus
Mohey, Hesham
Mojarrab, Javad
Mok, Maggie Ming Yee
Moncasi, Eduardo Parra
Moonen, Martial
Morales, Wenceslao Adrian Aguilera
Moreno, Eduardo Verde
Moreno, Antolina
Morris, Adam
Moutzouris, Dimitrios
Moya, Mercedes Gonzalez
Mucha, Simon
Musolino, Michela
Napodano, Pietro
Natario, Ana
Negrea, Lavinia
Nelson, Bradley
Neuen, Brendon
Newsome, Britt
Ng, Kit Chung Jack
Nguyen, Thu
Nguyen, Viet
Nicolo, Clementine
Nitschke, Martin
Noble, Euan
Nolasco, Fernando
O'Lone, Emma
Ochoa, Adriana Sierra
Oh, Kook-Hwan
Oh, SeWon
Okoh, Pedro
Ombelet, Sara
O'Shaughnessy, Michelle
Ou, Shih-Hsiang
Packham, David
Padiyar, Aparna
Pai, Mei-Fen
Pamplona, Irene Agraz
Pan, Szu-Yu
Pandya, Bhavna
Papadia, Federica
Pardinhas, Clara
Parikh, Nishita
Parikh, Samir
Park, Hyeong Cheon
Park, Jung Tak
Parreira, Lucia
Passerini, Patrizia
Patak, Ramachandra
Patecki, Margret
Patel, Rajan
Patel, Jusmin
Patel Suthar, Meera
Patella, Gemma
Patrikyan, Artashes
Pavlovic, Drasko
Paxton, William
Peh, Chen
Peleg, Yonatan
Pelicano, Josep Miquel Blasco
Peng, Yu-Sen
Pereira de Vicente, Manuel
Perez, Jonay Pantoja
Perez, Erika
Perez de Jose, Ana
Pérez Gómez, María Vanessa
Perez Lluna, Leticia
Peri, Usha
Perico, Norberto
Philipponnet, Carole
Phua, Elaine
Piel, Julia
Pillai, Unnikrishnan
Pilmore, Helen
Plavljanic, Djuro
Plaza, Mercedes Velo
Pollock, Carol
Ponnusamy, Arvind
Ponti, Serena
Powell, Thomas
Pradhan, Nishigandha
Prado, Raul Fernandez
Prkacin, Ingrid
Pruthi, Rishi
Pugh, Dan
Quinn, Sarah
Quintana, Luis F
Raakesh, Lathika
Rabindranath, Kannaiyan
Radermacher, Luc
Radhakrishnan, Jai
Ragy, Omar Sherin Ibrahim
Raichoudhury, Ritesh
Raimundo, Mario
Randone, Paolo
Razavian, Mona
Reichel, Helmut
Reis, Marina
Remuzzi, Giuseppe
Reynolds, Annie
Ricchiuto, Anna
Rico, Ivon Maritza Bobadilla
Rigothier, Claire
Ritchie, Angus
Rivero, Maria Antonieta Azancot
Rizk, Dana
Ro, Han
Rodriguez, Alfred
Rodriguez Garcia, Eva
Roger, Simon
Rony, Mohammad
Rosenberg, Mai
Roueff, Stephane
Rovin, Brad
Roxburgh, Sarah
Ruiz, Mario
Rusinol, Helena Marco
Rychlik, Ivan
Sá, Helena
Salehi, Tania
Sánchez de la Nieta, Maria Dolores
Sanden, Silja
Santockiene, Lina
Santos, Patricia Valerio
Santos, Iara Da Silva
Sargsyan, Mari
Sarnow, Franziska
Sat, Sebahat
Satora, Ewa
Savuk, Ana
Sayer, Matthew
Schlieper, Georg
Schlosser, Mandy
Schmidt-Guertler, Hans
Schockaert, Olivier
Schulte, Kevin
Schulz, Lisa
Selvaskandan, Haresh
Semple, David
Sen, Shaundeep
Seppet, Elviira
Serrano, Antonio Galan
Serre, Jean-Emmanuel
Sevillano, Angel
Shah, Sapna
Shen, Yvonne
Sheridan, Brittany
Shu, Kai-Hsiang
Sightler, Ford
Silva, Sónia
Silva, Arnold
Sinha, Smeeta
Siriwardana, Amanda
Sitas, Zvonimir
Sivo, Carmen
Sizeland, Peter
Sly, Cathylee
Smith, Priscilla
Snow, Brian
Soares, Elsa Sofia Quadrado
Solazzo, Andrea
Solis, Elena Gutierrez
Solomon, Laurence
Song, Young Rim
Sousa, Helena
Spinowitz, Bruce
Stallworthy, Elizabeth
Stamellou, Eleni
Stanczyk, Malgorzata
Stangenberg, Stefanie
Stankovic, Marija
Stankuviene, Asta
Stea, Emma Diletta
Stompor, Tomasz
Storrar, Joshua
Sullivan, James
Sulowicz, Wladyslaw
Suyumova, Irina
Szeto, Cheuk Chun
Tamarit, Esther
Tan, Eddie
Tan, May
Tang, Sydney Chi Wai
Tang, Hon
Teixeira, Catarina
Telling, Kadri
Terrades, Natalia Ramos
Tesar, Vladimir
Tez, Didem
Thervet, Eric
Thibaudin, Damien
Thomas, Mark
Thyagarajan, Nikhil
Tkaczyk, Marcin
Torreggiani, Massimo
Trillini, Matias
Tsai, Shang-Feng
Tsai, Wan-Chuan
Tsai, Jer-Chia
Tseng, Po-Yu
Tumlin, James
Tung, Kuei-Ting
Turnbull, Angus
Udani, Suneel
Uhlinova, Jana
Unt, Kristin
Urciuolo, Federica
Vanacker, An
Vandewiele, Bert
Vaz, Alvaro
Veermae, Kristi
Viaene, Liesbeth
Vickiene, Alvita
Vigano, Sara
Vila, Maria Antonia Munar
Vilayur, Eswari
Villanueva, Caridad Martinez
Villarroya, Cristina Medrano
Villen, Alejandro Soria
Viramontes, Veronica
Vita, Caterina
Vujcic, Dunja
Wahba, Mona
Wan, Susan
Wang, Chih-Hsien
Warling, Xavier
Waters, Gerald
Waugh, Jane
Weiland, Lea
Weiner, Stefan
Weinreich, Thomas
Werth, Stephan Christian
Wickens, Olivia
Wijeratne, Vidu
Wilder, Karen
Willcocks, Lisa
Williams, Allister
Winiarska, Agata
Wirtz, Nikolaus
Wolf, Lothar
Wolf, Gunter
Wong, Muh Geot
Wong, Yick Hei
Wong, Sze Ho Sunny
Workeneh, Biruh
Wu, Ming-Ju
Wu, Hon-Yen
Wyndham, Roger
Yang, Jihyun
Yang, Ju-Yeh
Yeap, Chii
Yim, Ka Fai
Yong, Kenneth
Yoo, Tae-Hyun
Yoon, Songuk
Yu, Tung-Min
Yue, Tak Tai Andrew
Zakari, Michel
Zakauskiene, Urte
Zaoui, Philippe
Zbrzezniak, Justyna
Zielinska, Dorota
Zizzi, Carlotta Federica
Rovin, Brad H ^{*, *}
Heerspink, Hiddo J L
Alpers, Charles E
Bieler, Stewart
Diva, Ulysses A
Inrig, Jula K
Kohan, Donald E
Komers, Radko
Małecki, Robert
Mercer, Alex
Noronha, Irene L
Oh, Se Won
Peh, Chen Au
Praga, Manuel
Preciado, Priscila
Rheault, Michelle N
Rote, William E
Tang, Sydney C W
Trachtman, Howard
Trimarchi, Hernán
Tumlin, James A
Perkovic, Vlado
DB Label: Database : ScienceDirect

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Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial

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