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1
Characterization of 2,4-Dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3, PfNEK3, PfPK9, and PfPKB. 미리보기

학술저널

issue
ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Nov 27; Vol. 14 (12), pp. 1774-1784. Date of Electronic Publication: 2023 Nov 27 (Print Publication: 2023).
Author
Ong HW; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
de Silva C; Luceome Biotechnologies, LLC, 1665 East 18th Street, Suite 106, Tucson, Arizona 85719, United States.
Avalani K; Luceome Biotechnologies, LLC, 1665 East 18th Street, Suite 106, Tucson, Arizona 85719, United States.
Kwarcinski F; Luceome Biotechnologies, LLC, 1665 East 18th Street, Suite 106, Tucson, Arizona 85719, United States.
Mansfield CR; Department of Molecular Genetics and Microbiology, Duke University Medical Center, 213 Research Drive, Durham, North Carolina 27710, United States.
Chirgwin M; Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708, United States.
Truong A; Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708, United States.
Derbyshire ER; Department of Molecular Genetics and Microbiology, Duke University Medical Center, 213 Research Drive, Durham, North Carolina 27710, United States.; Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708, United States.
Zutshi R; Luceome Biotechnologies, LLC, 1665 East 18th Street, Suite 106, Tucson, Arizona 85719, United States.
Drewry DH; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; Lineberger Comprehensive Cancer Center, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
DB Label
Database : MEDLINE
원문보기
Full Text (ACS)  등재 - Web of Science (SCIE)  등재 - SCOPUS  조회 - Impact Factor (JCR) 
2
Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore. 미리보기

학술저널

issue
European journal of medicinal chemistry [Eur J Med Chem] 2023 Mar 05; Vol. 249, pp. 115043. Date of Electronic Publication: 2022 Dec 30.
Author
Ong HW; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Truong A; Department of Chemistry, Duke University, 124 Science Drive, Durham, NC, 27708, USA.
Kwarcinski F; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, AZ, 85719, USA.
de Silva C; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, AZ, 85719, USA.
Avalani K; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, AZ, 85719, USA.
Havener TM; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Chirgwin M; Department of Chemistry, Duke University, 124 Science Drive, Durham, NC, 27708, USA.
Galal KA; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Willis C; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, AZ, 85719, USA.
Krämer A; Structural Genomics Consortium, Institute of Pharmaceutical Chemistry, Goethe University Frankfurt am Main, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.
Liu S; Research Computing Center, University of North Carolina, Chapel Hill, NC, 27599-3420, USA; Department of Chemistry, University of North Carolina, Chapel Hill, NC, 27599-3420, USA.
Knapp S; Structural Genomics Consortium, Institute of Pharmaceutical Chemistry, Goethe University Frankfurt am Main, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.
Derbyshire ER; Department of Chemistry, Duke University, 124 Science Drive, Durham, NC, 27708, USA; Department of Molecular Genetics and Microbiology, Duke University Medical Center, 213 Research Drive, Durham, NC, 27710, USA. Electronic address: emily.derbyshire@duke.edu.
Zutshi R; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, AZ, 85719, USA. Electronic address: reena.zutshi@luceome.com.
Drewry DH; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Lineberger Comprehensive Cancer Center, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Electronic address: david.drewry@unc.edu.
DB Label
Database : MEDLINE
원문보기
Full Text (ScienceDirect)  등재 - Web of Science (SCIE)  조회 - Impact Factor (JCR) 
3
Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial Pf GSK3/ Pf PK6 with Activity against Blood Stage Parasites In Vitro. 미리보기

학술저널

issue
Journal of medicinal chemistry [J Med Chem] 2022 Oct 13; Vol. 65 (19), pp. 13172-13197. Date of Electronic Publication: 2022 Sep 27.
Author
Galal KA; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Truong A; Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708, United States.
Kwarcinski F; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, Arizona 85719, United States.
de Silva C; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, Arizona 85719, United States.
Avalani K; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, Arizona 85719, United States.
Havener TM; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Chirgwin ME; Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708, United States.
Merten E; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Ong HW; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Willis C; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, Arizona 85719, United States.
Abdelwaly A; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza 12587, Egypt.
Helal MA; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza 12587, Egypt.; Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
Derbyshire ER; Department of Chemistry, Duke University, 124 Science Drive, Durham, North Carolina 27708, United States.; Department of Molecular Genetics and Microbiology, Duke University Medical Center, 213 Research Drive, Durham, North Carolina 27710, United States.
Zutshi R; Luceome Biotechnologies, L.L.C, 1665 E. 18th Street, Suite 106, Tucson, Arizona 85719, United States.
Drewry DH; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.; Lineberger Comprehensive Cancer Center, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
DB Label
Database : MEDLINE
원문보기
Full Text (ACS)  등재 - Web of Science (SCIE)  등재 - SCOPUS  조회 - Impact Factor (JCR) 
1 
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